Wednesday, September 14, 2005

Journal of Clinical Psychiatry Publishes Two-Year Results From Cyberonics' Depression Pilot Study

Corporate Press Release

"HOUSTON, Sept. 13 /PRNewswire-FirstCall/ -- Cyberonics, Inc. (Nasdaq: CYBX) today announced that the peer-reviewed two-year results from its treatment-resistant depression D-01 pilot study were published in the September 2005 issue of the Journal of Clinical Psychiatry (J. Clin Psychiatry 66:9, September 2005).

The article, entitled "Two-Year Outcome of Vagus Nerve Stimulation (VNS) for Treatment of Major Depressive Episodes"; by Ziad Nahas, M.D., Associate Professor at Medical University of South Carolina (MUSC); Medical Director of Brain Stimulation Lab at MUSC; and Director of Mood Disorder Program at MUSC, et al, presents the three-month, one-year and two- year response and remission rates from the 60-patient VNS pilot study conducted at Medical University of South Carolina, Baylor College of Medicine, University of Texas Southwestern Medical Center and Columbia University.

Based on last observation carried forward analyses, HAM-D response rates were 42% and HAM-D remission rates were 22% after two years of adjunctive VNS Therapy(TM) in patients that had received a mean of 15.7 unsuccessful clinical treatments in the current depressive episode, the median of which was 6.8 years. At two years, 81% of the study participants were still receiving VNS Therapy."